Dissecting the properties of circulating IgG against streptococcal pathogens through a combined systems antigenomics-serology workflow
Abstract This study showcases an integrative mass spectrometry-based strategy combining systems antigenomics and systems serology to characterize human antibodies in clinical samples.This strategy involves using antibodies circulating in plasma to affinity-enrich antigenic proteins in biochemically fractionated pools of bacterial proteins, followed